After a recent appearance to promote his show Living Biblically at the TCA conference, series star Johnny Galecki. Per TVLine, Galecki offered this statement regarding The Big Bang Theory's future:
"The only manner in which the cast has discussed wrapping [The Big Bang Theory] has been that we're all going to be very sad when that day comes," Galecki told reporters on Saturday. "But I think at this point everyone's very comfortable with 12 seasons being a good time to go home and see our families."

12 seasons seems to be a stopping point for successful Chuck Lorre franchises. In 2015, Two and a Half Men also ended its run at the same benchmark after recent seasons delivered modest deliveries. In 2017, the stars of TBBT all inked two-year extensions onto their contracts, guaranteeing the series' renewal for that period. Their contracts are the hinging factor for the show's renewal, foreshadowing it may be time to come to a close in 2019.